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Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?

Authors :
Wang MX
Gao SY
Yang F
Fan RJ
Yang QN
Zhang TL
Qian NS
Dai GH
Source :
World journal of clinical oncology [World J Clin Oncol] 2022 Sep 24; Vol. 13 (9), pp. 729-737.
Publication Year :
2022

Abstract

Immunotherapy has shown great promise in treating various types of malignant tumors. However, some patients with gastrointestinal cancer have been known to experience rapid disease progression after treatment, a situation referred to as hyperprogressive disease (HPD). This minireview focuses on the definitions and potential mechanisms of HPD, natural disease progression in gastrointestinal malignancies, and tumor immunological microenvironment.<br />Competing Interests: Conflict-of-interest statement: All authors declare that there are no conflicts of interest for this article.<br /> (©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.)

Details

Language :
English
ISSN :
2218-4333
Volume :
13
Issue :
9
Database :
MEDLINE
Journal :
World journal of clinical oncology
Publication Type :
Academic Journal
Accession number :
36212599
Full Text :
https://doi.org/10.5306/wjco.v13.i9.729