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Associations of Pulmonary Function with MRI Brain Volumes: A Coordinated Multi-Study Analysis.

Authors :
Frenzel S
Bis JC
Gudmundsson EF
O'Donnell A
Simino J
Yaqub A
Bartz TM
Brusselle GGO
Bülow R
DeCarli CS
Ewert R
Gharib SA
Ghosh S
Gireud-Goss M
Gottesman RF
Ikram MA
Knopman DS
Launer LJ
London SJ
Longstreth WT
Lopez OL
Melo van Lent D
O'Connor G
Satizabal CL
Shrestha S
Sigurdsson S
Stubbe B
Talluri R
Vasan RS
Vernooij MW
Völzke H
Wiggins KL
Yu B
Beiser AS
Gudnason V
Mosley T
Psaty BM
Wolters FJ
Grabe HJ
Seshadri S
Source :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 90 (3), pp. 1073-1083.
Publication Year :
2022

Abstract

Background: Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.<br />Objective: To study the cross-sectional associations of pulmonary function with structural brain variables.<br />Methods: Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements were standardized with respect to age, sex, height, and ethnicity using reference equations of the Global Lung Function Initiative. Associations of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and their ratio FEV1/FVC with brain volume, gray matter volume, hippocampal volume, and volume of white matter hyperintensities were investigated using multivariable linear regressions for each study separately and then combined using random-effect meta-analyses.<br />Results: FEV1 and FVC were positively associated with brain volume, gray matter volume, and hippocampal volume, and negatively associated with white matter hyperintensities volume after multiple testing correction, with little heterogeneity present between the studies. For instance, an increase of FVC by one unit was associated with 3.5 ml higher brain volume (95% CI: [2.2, 4.9]). In contrast, results for FEV1/FVC were more heterogeneous across studies, with significant positive associations with brain volume, gray matter volume, and hippocampal volume, but not white matter hyperintensities volume. Associations of brain variables with both FEV1 and FVC were consistently stronger than with FEV1/FVC, specifically with brain volume and white matter hyperintensities volume.<br />Conclusion: In cross-sectional analyses, worse pulmonary function is associated with smaller brain volumes and higher white matter hyperintensities burden.

Details

Language :
English
ISSN :
1875-8908
Volume :
90
Issue :
3
Database :
MEDLINE
Journal :
Journal of Alzheimer's disease : JAD
Publication Type :
Academic Journal
Accession number :
36213999
Full Text :
https://doi.org/10.3233/JAD-220667