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Fibrinolytic Changes in Women with Preeclampsia.
- Source :
-
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2022 Jan-Dec; Vol. 28, pp. 10760296221126172. - Publication Year :
- 2022
-
Abstract
- Objectives: Preeclampsia (PE) is a serious complication of pregnancy. The fibrinolytic system play crucial roles regarding placentation and evolution of PE.<br />Aim: To study comprehensively components of the fibrinolytic system and fibrin lysability in women with PE.<br />Design and Methods: 117 women with PE and matched controls were included. Tissue type plasminogen activator (t-PA), plasminogen, PAI-1, plasmin inhibitor (PI), D-dimer, the fibrinolytic potential of dextran sulphate euglobulin fraction (DEF), PAI-2, polymere PAI-2, fibrin clot lysability, thrombin activatable fibrinolysis inhibitor (TAFI) and fibrinogen were assessed.<br />Results: Women with PE had significantly increased concentrations of t-PA and PAI-1, whereas the plasma concentration of PAI-2 was significantly lower compared to controls, p < 0.0001. Polymere PAI-2 was detected in both groups. DEF, TAFI and fibrinogen were not different between the groups. D-dimer was significantly increased and plasminogen/PI together with fibrin clot lysability time decreased in the PE-group, p = 0.0004 p = 0.04, p = 0.03, p < 0.0001 respectively.<br />Conclusion: This study demonstrates that PE is associated with an affected t-PA/PAI-1 system, decreased PAI-2 and increased fibrin lysability. Furthermore, PAI-2 has the potential to polymerize during pregnancy.
- Subjects :
- Female
Humans
Pregnancy
Dextran Sulfate pharmacology
Fibrin
Fibrinogen pharmacology
Fibrinolysis
Plasminogen pharmacology
Plasminogen Activator Inhibitor 1
Plasminogen Activator Inhibitor 2 pharmacology
Tissue Plasminogen Activator
Antifibrinolytic Agents
Carboxypeptidase B2
Pre-Eclampsia
Thrombosis
Subjects
Details
- Language :
- English
- ISSN :
- 1938-2723
- Volume :
- 28
- Database :
- MEDLINE
- Journal :
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
- Publication Type :
- Academic Journal
- Accession number :
- 36217728
- Full Text :
- https://doi.org/10.1177/10760296221126172