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Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil.

Authors :
Torres K
Ferreira MU
Castro MC
Escalante AA
Conn JE
Villasis E
da Silva Araujo M
Almeida G
Rodrigues PT
Corder RM
Fernandes ARJ
Calil PR
Ladeia WA
Garcia-Castillo SS
Gomez J
do Valle Antonelli LR
Gazzinelli RT
Golenbock DT
Llanos-Cuentas A
Gamboa D
Vinetz JM
Source :
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2022 Oct 11; Vol. 107 (4_Suppl), pp. 168-181. Date of Electronic Publication: 2022 Oct 11 (Print Publication: 2022).
Publication Year :
2022

Abstract

The 1990s saw the rapid reemergence of malaria in Amazonia, where it remains an important public health priority in South America. The Amazonian International Center of Excellence in Malaria Research (ICEMR) was designed to take a multidisciplinary approach toward identifying novel malaria control and elimination strategies. Based on geographically and epidemiologically distinct sites in the Northeastern Peruvian and Western Brazilian Amazon regions, synergistic projects integrate malaria epidemiology, vector biology, and immunology. The Amazonian ICEMR's overarching goal is to understand how human behavior and other sociodemographic features of human reservoirs of transmission-predominantly asymptomatically parasitemic people-interact with the major Amazonian malaria vector, Nyssorhynchus (formerly Anopheles) darlingi, and with human immune responses to maintain malaria resilience and continued endemicity in a hypoendemic setting. Here, we will review Amazonian ICEMR's achievements on the synergies among malaria epidemiology, Plasmodium-vector interactions, and immune response, and how those provide a roadmap for further research, and, most importantly, point toward how to achieve malaria control and elimination in the Americas.

Details

Language :
English
ISSN :
1476-1645
Volume :
107
Issue :
4_Suppl
Database :
MEDLINE
Journal :
The American journal of tropical medicine and hygiene
Publication Type :
Academic Journal
Accession number :
36228921
Full Text :
https://doi.org/10.4269/ajtmh.22-0127