Back to Search
Start Over
Exceptional Response to Erdafitinib in FGFR2-Mutated Metastatic Pancreatic Ductal Adenocarcinoma.
- Source :
-
Journal of the National Comprehensive Cancer Network : JNCCN [J Natl Compr Canc Netw] 2022 Oct; Vol. 20 (10), pp. 1076-1079. - Publication Year :
- 2022
-
Abstract
- Despite advances in cancer therapeutics, pancreatic ductal adenocarcinoma (PDAC) remains among the deadliest malignancies, with a poor prognosis at time of diagnosis. Research in PDAC has suggested that adaptive signaling in the tumor microenvironment may promote tumor proliferation and survival. Several FGFR fusion genes-specifically FGFR2-are involved with the creation and progression of cancer. These mutations are found in a variety of cancer types. This report presents a unique case of a young patient with stage IV PDAC with a known FGFR2 fusion. This molecular alteration afforded a remarkable response to FGFR inhibitor therapy, erdafitinib, after the patient experienced disease progression on multiple chemotherapy regimens.
- Subjects :
- Humans
Pyrazoles
Quinoxalines
Receptor, Fibroblast Growth Factor, Type 2 genetics
Receptor, Fibroblast Growth Factor, Type 2 therapeutic use
Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma genetics
Carcinoma, Pancreatic Ductal drug therapy
Carcinoma, Pancreatic Ductal genetics
Pancreatic Neoplasms drug therapy
Pancreatic Neoplasms genetics
Pancreatic Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-1413
- Volume :
- 20
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of the National Comprehensive Cancer Network : JNCCN
- Publication Type :
- Academic Journal
- Accession number :
- 36240849
- Full Text :
- https://doi.org/10.6004/jnccn.2022.7039