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Pre- and Early Peri-menopausal Physical Function and Risk of Cardiovascular Events: The Study of Women's Health Across the Nation.
- Source :
-
Journal of aging and health [J Aging Health] 2023 Jun; Vol. 35 (5-6), pp. 383-391. Date of Electronic Publication: 2022 Oct 17. - Publication Year :
- 2023
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Abstract
- Objectives: To determine whether physical function (PF) before menopause is related to cardiovascular disease (CVD) risk.<br />Methods: Participants were N = 2950 pre-/early peri-menopausal women (median age 46, (25th-75th percentile: 43-48 years). Physical function was assessed at baseline using the Physical Function subscale of the SF-36 and scores were trichotomized (no, some, or substantial limitations). Clinical CVD events were ascertained at annual/biennial clinical assessments through the 15th follow-up visit. Risk of CVD was determined with Cox proportional hazards models. Results: Women were followed for a median of 19.1 years, during which 220 women had a CVD event. In fully adjusted models, women with substantial limitations at baseline had higher CVD risk compared to women with no limitations (hazards ratio [HR] = 1.55, 95% confidence interval [CI]: 1.12-2.33). Discussion: Substantial PF limitations in pre- and early peri-menopausal women are associated with higher risk of clinical CVD events, consistent with literature in older adults.
Details
- Language :
- English
- ISSN :
- 1552-6887
- Volume :
- 35
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Journal of aging and health
- Publication Type :
- Academic Journal
- Accession number :
- 36250945
- Full Text :
- https://doi.org/10.1177/08982643221133580