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Effects of a high-fat meal on inflammatory and endothelial injury biomarkers in accordance with adiposity status: a cross-sectional study.
- Source :
-
Nutrition journal [Nutr J] 2022 Oct 19; Vol. 21 (1), pp. 65. Date of Electronic Publication: 2022 Oct 19. - Publication Year :
- 2022
-
Abstract
- Background: It is known that consuming a high-fat meal (HFM) induces microvascular dysfunction (MD) in eutrophic women and aggravates it in those with obesity. Our purpose was to investigate if the MD observed after a single HFM intake is caused by endothelial damage or increased inflammatory state, both determined by blood biomarkers.<br />Methods: Nineteen women with obesity (BMI 30-34.9 kg/m <superscript>2</superscript> ) and 18 eutrophic ones (BMI 20.0-24.9 kg/m <superscript>2</superscript> ) were enrolled into two groups: Obese (OBG) and Control (CG), respectively. Blood samples were collected at five-time points: before (fasting state) and 30, 60, 120, and 180 min after HFM intake to determine levels of adipokines (adiponectin, leptin), non-esterified fatty acid (NEFA), inflammatory [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)] and endothelium damage [soluble E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor-1 (PAI-1)] biomarkers.<br />Results: Levels of soluble E-selectin, leptin, and PAI-1 were higher in OBG at all-time points (P < 0.05) compared to CG. In the fasting state, OBG had higher levels of NEFA compared to CG (P < 0.05). In intra-group analysis, no significant change in the levels of circulating inflammatory and endothelial injury biomarkers was observed after HFM intake, independently of the group.<br />Conclusion: Our findings suggest that women with obesity have an increased pro-inflammatory state and more significant endothelial injury compared to eutrophic ones. However, the consumption of a HFM was not sufficient to change circulating levels of inflammatory and endothelial injury biomarkers in either group.<br />Registration Number for Clinical Trials: NCT01692327.<br /> (© 2022. The Author(s).)
- Subjects :
- Female
Humans
Adipokines
Adiponectin
Biomarkers
Cross-Sectional Studies
E-Selectin metabolism
Endothelium, Vascular
Fatty Acids, Nonesterified
Intercellular Adhesion Molecule-1 metabolism
Intercellular Adhesion Molecule-1 pharmacology
Interleukin-6
Obesity
Plasminogen Activator Inhibitor 1 metabolism
Plasminogen Activator Inhibitor 1 pharmacology
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1 metabolism
Vascular Cell Adhesion Molecule-1 pharmacology
Adiposity
Leptin
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2891
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrition journal
- Publication Type :
- Academic Journal
- Accession number :
- 36258233
- Full Text :
- https://doi.org/10.1186/s12937-022-00819-4