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cAMP signaling in ovarian physiology in teleosts: A review.

cAMP signaling in ovarian physiology in teleosts: A review.

Authors :
Takahashi T
Ogiwara K
Source :
Cellular signalling [Cell Signal] 2023 Jan; Vol. 101, pp. 110499. Date of Electronic Publication: 2022 Oct 21.
Publication Year :
2023

Abstract

Ovarian function in teleosts, like in other vertebrates, is regulated by two distinct gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Gonadotropin effects are mediated by membrane-bound G protein-coupled receptors localized on the surface of follicle cells. Gonadotropin receptor activation results in increased intracellular cAMP, the most important second cellular signaling molecule. FSH stimulation induces the production of 17β-estradiol in the cells of growing follicles to promote vitellogenesis in oocytes. In contrast, in response to LH, fully grown post-vitellogenic follicles gain the ability to synthesize maturation-inducing steroids, which induce meiotic resumption and ovulation. All these events were induced downstream of cAMP. In this review, we summarize studies addressing the role of the cAMP pathway in gonadotropin-induced processes in teleost ovarian follicles. Furthermore, we discuss future problems concerning cAMP signaling in relation to teleost ovarian function and the differences and similarities in the gonadotropin-induced cAMP signaling pathways between mammals and teleosts.<br />Competing Interests: Declaration of Competing Interest Authors declare no competing interest.<br /> (Copyright © 2022. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1873-3913
Volume :
101
Database :
MEDLINE
Journal :
Cellular signalling
Publication Type :
Academic Journal
Accession number :
36273754
Full Text :
https://doi.org/10.1016/j.cellsig.2022.110499