Back to Search
Start Over
KI-Catalyzed Oxidative Cyclization of Enamines and t BuONO to Access Functional Imidazole-4-Carboxylic Derivatives.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2022 Nov 18; Vol. 87 (22), pp. 15380-15388. Date of Electronic Publication: 2022 Nov 01. - Publication Year :
- 2022
-
Abstract
- A simple protocol for the noble-metal-free oxidative cyclization of enamines and <superscript> t </superscript> BuONO has been developed. This KI-mediated formal [4 + 1] cycloamination reaction provides a practical strategy for the synthesis of imidazole-4-carboxylic derivatives using <superscript> t </superscript> BuONO both as an aminating reagent and oxidant. The reaction features wide substrate scope and good functional tolerance for enamine compounds, even the unactivated ones.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 87
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36317961
- Full Text :
- https://doi.org/10.1021/acs.joc.2c01943