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Targeting PDAC metabolism: Environment determines what has GOT2 give.
- Source :
-
Cell metabolism [Cell Metab] 2022 Nov 01; Vol. 34 (11), pp. 1617-1619. - Publication Year :
- 2022
-
Abstract
- Metabolic disruption is a mainstay of cancer therapy, prompting research aimed at identifying novel metabolic targets. Despite strong effects observed in culture, three recent studies found pancreatic tumors are refractory to disruption of the metabolic enzyme GOT2, revealing complex interactions within the tumor microenvironment that bypass its conventional metabolic roles.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1932-7420
- Volume :
- 34
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 36323232
- Full Text :
- https://doi.org/10.1016/j.cmet.2022.09.027