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Utility of ultrasonography for predicting indications for tolvaptan in patients with autosomal dominant polycystic kidney disease.
- Source :
-
Journal of medical ultrasonics (2001) [J Med Ultrason (2001)] 2023 Jan; Vol. 50 (1), pp. 81-87. Date of Electronic Publication: 2022 Nov 05. - Publication Year :
- 2023
-
Abstract
- Purpose: Tolvaptan is the first approved treatment for autosomal dominant polycystic kidney disease (ADPKD) that targets a mechanism directly contributing to the development and growth of renal cysts. We investigated the ability of ultrasonography to predict total kidney volume (TKV) of 750 mL or more, which is an indication for tolvaptan therapy in patients with ADPKD.<br />Methods: A total of 46 patients with ADPKD were evaluated. The most statistically appropriate measurement based on ultrasonography for predicting TKV determined by computed tomography (CT) was assessed.<br />Results: TKV determined by CT was 796.8 (508.8-1,560.3) mL. The median length, anteroposterior distance, and mediolateral distance determined using ultrasonography were 15.7 cm, 7.6 cm, and 7.6 cm in the left kidney, and 13.4 cm, 6.9 cm, and 7.2 cm in the right kidney, respectively. Multivariate regression analysis showed that total kidney length (left and right) [variance inflation factor (VIF), 9.349] and total mediolateral distance (left and right) (VIF, 3.988) were independently associated with TKV. The correlation (r) between the logarithm of TKV determined by CT and total mediolateral distance determined using ultrasonography was 0.915 (p < 0.001). The linear regression equation was log (total kidney volume) = 1.833 + 0.075 × total mediolateral distance (left and right) based on ultrasonography. The area under the receiver operating characteristic curve for total mediolateral distance determined using ultrasonography to predict TKV of 750 mL or more was 0.989. Using the total mediolateral distance cut-off value of 14.2 cm, the sensitivity and specificity were 96.0% and 100.0%, respectively.<br />Conclusion: Total mediolateral distance determined using ultrasonography can predict TKV in patients with ADPKD.<br /> (© 2022. The Author(s).)
- Subjects :
- Humans
Tolvaptan therapeutic use
Antidiuretic Hormone Receptor Antagonists therapeutic use
Disease Progression
Glomerular Filtration Rate
Kidney diagnostic imaging
Ultrasonography
Polycystic Kidney, Autosomal Dominant complications
Polycystic Kidney, Autosomal Dominant diagnostic imaging
Polycystic Kidney, Autosomal Dominant drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1613-2254
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of medical ultrasonics (2001)
- Publication Type :
- Academic Journal
- Accession number :
- 36333536
- Full Text :
- https://doi.org/10.1007/s10396-022-01261-z