Stimuli-responsive transdermal microneedle patches.

Authors :: Makvandi P
Jamaledin R
Chen G
Baghbantaraghdari Z
Zare EN
Di Natale C
Onesto V
Vecchione R
Lee J
Tay FR
Netti P
Mattoli V
Jaklenec A
Gu Z
Langer R
Source :: Materials today (Kidlington, England) [Mater Today (Kidlington)] 2021 Jul-Aug; Vol. 47, pp. 206-222. Date of Electronic Publication: 2021 May 20.
Publication Year :: 2021
Abstract: Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the stratum corneum and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.<br />Competing Interests: Competing interests Z.G. is a scientific co-founder of Zenomics Inc. and Zcapsule Inc. R.L. is a scientific advisor to Zenomic Inc. and Zcapsule Inc. For a list of entities with which R.L. is involved, compensated or uncompensated, see https://tinyurl.com/RLCOINBME. The remaining authors declare no competing interests.