Association Between the Development of Subclinical Cardiovascular Disease and Human Immunodeficiency Virus (HIV) Reservoir Markers in People With HIV on Suppressive Antiretroviral Therapy.

We report that people with human immunodeficiency virus (HIV) diagnosed with coronary artery atherosclerotic plaques display higher levels of HIV DNA compared with those without atherosclerotic plaques. In a multivariable prediction model that included 27 traditional and HIV-related risk factors, measures of HIV DNA were among the most important predictors of atherosclerotic plaque formation.
Competing Interests: Potential conflicts of interest. J.-G. B. reports consulting fees paid to the author not related to this work from Gilead Sciences, Merck, and ViiV healthcare; payment for lectures not related to this work from Gilead Science and Merck. C. C.-L. reports grants or contracts unrelated to this work from Fonds de recherche santé Québec and Réseau SIDA-MI. M. D. is a member of the steering committee of the Canadian HIV Clinical Trial Network. M. E.-F. reports funding through NIH #R01AG054324. M.-A. J. reports funds from the Canadian Institutes of Health Research (CIHR), Team Grant #HAL-157985, as part of the Canadian HIV and aging study. C. L. T. reports grants or contracts from Merck, Gilead, CIHR, and NIH; consulting fees from Merck, GSK, Medicago, Gilead, AstraZeneca, and Moderna; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Merck, GSK, AstraZeneca, Gilead, Pfizer, Sanofi; support for attending meetings and/or travel from Moderna; participation on a Data Safety Monitoring Board or Advisory Board for Colcorona, Dalcor, and Hesperidin. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
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