Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model.

Authors :: Faid AH
Shouman SA
Badr YA
Sharaky M
Source :: BMC chemistry [BMC Chem] 2022 Nov 09; Vol. 16 (1), pp. 90. Date of Electronic Publication: 2022 Nov 09.
Publication Year :: 2022
Abstract: Background: The difficulty of achieving targeted drug delivery following administration of presently marketed anticancer therapeutics is still a concern. Metallic nanoparticles (NPs) appear to be promising in this regard. The present study focused on the use of gold nanoparticles (AuNPs) as a drug carrier for anticancer Doxorubicin (DOX) forming DOX-AuNPs nanocomposite. The anticancer effect of the prepared nanocomposite was evaluated using SRP essay on breast cancer cell line (MCF7) for different incubation times (24 h,48, and72hr). The prepared DOX-AuNPs nanocomposite was investigated by UV-visible spectroscopy, TEM, fluorescence spectroscopy, and FTIR spectroscopy.<br />Results: Our results showed that the prepared AuNPs and DOX-AuNPs nanocomposite have spherical and small size10 ± 2 nm and 12 ± 2 nm respectively. The potential cytotoxicity of the DOX-AuNPs nanocomposite on the MCF7 cell line was significantly increased compared to free DOX. The 20 µM DOX- AuNPs nanocomposite produced a similar decrease in cell survival as 80 µM free DOX.<br />Conclusion: Future work is in progress to investigate the positive effects of the prepared nanocomposite for chemo-photothermal combination treatment.<br /> (© 2022. The Author(s).)

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