Back to Search
Start Over
18 F-PSMA Cerenkov Luminescence and Flexible Autoradiography Imaging in a Prostate Cancer Mouse Model and First Results of a Radical Prostatectomy Feasibility Study in Men.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2023 Apr; Vol. 64 (4), pp. 598-604. Date of Electronic Publication: 2022 Nov 10. - Publication Year :
- 2023
-
Abstract
- Intraoperative identification of positive resection margins (PRMs) in high-risk prostate cancer (PC) needs improvement. Cerenkov luminescence imaging (CLI) with <superscript>68</superscript> Ga-PSMA-11 is promising, although limited by low residual activity and artificial signals. Here, we aimed to assess the value of CLI and flexible autoradiography (FAR) with <superscript>18</superscript> F-PSMA-1007. Methods: Mice bearing subcutaneous PSMA-avid RM1-PGLS tumors were administered <superscript>18</superscript> F-PSMA-1007, and PET/CT was performed. After the animals had been killed, organs were excised and measured signals in CLI and FAR CLI were correlated with tracer activity concentrations (ACs) obtained from PET/CT. For clinical assessment, 7 high-risk PC patients underwent radical prostatectomy immediately after preoperative <superscript>18</superscript> F-PSMA PET/CT. Contrast-to-noise ratios (CNRs) were calculated for both imaging modalities in intact specimens and after incision above the index lesion. Results: In the heterotopic in vivo mouse model ( n = 5), CLI did not detect any lesion. FAR CLI detected a distinct signal in all mice, with a lowest AC of 7.25 kBq/mL (CNR, 5.48). After incision above the index lesion of the prostate specimen, no increased signal was observed at the cancer area in CLI. In contrast, using FAR CLI, a signal was detectable in 6 of 7 patients. The AC in the missed index lesion was 1.85 kBq/mL, resulting in a detection limit of at least 2.06 kBq/mL. Histopathology demonstrated 2 PRMs, neither of which was predicted by CLI or FAR CLI. Conclusion: <superscript>18</superscript> F-PSMA FAR CLI was superior to CLI in tracer-related signal detectability. PC was could be visualized in radical prostatectomy down to 2.06 kBq/mL. However, the detection of PRMs was limited. Direct anatomic correlation of FAR CLI is challenging because of the scintillator overlay.<br /> (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)
- Subjects :
- Humans
Male
Animals
Mice
Positron Emission Tomography Computed Tomography methods
Positron-Emission Tomography methods
Autoradiography
Luminescence
Feasibility Studies
Gallium Radioisotopes
Prostatectomy methods
Prostate diagnostic imaging
Prostate surgery
Prostate pathology
Prostatic Neoplasms diagnostic imaging
Prostatic Neoplasms surgery
Prostatic Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1535-5667
- Volume :
- 64
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 36357181
- Full Text :
- https://doi.org/10.2967/jnumed.122.264670