Back to Search Start Over

The multidisciplinary management of cholangiocarcinoma.

The multidisciplinary management of cholangiocarcinoma.

Authors :
Ohaegbulam KC
Koethe Y
Fung A
Mayo SC
Grossberg AJ
Chen EY
Sharzehi K
Kardosh A
Farsad K
Rocha FG
Thomas CR
Nabavizadeh N
Source :
Cancer [Cancer] 2023 Jan 15; Vol. 129 (2), pp. 184-214. Date of Electronic Publication: 2022 Nov 16.
Publication Year :
2023

Abstract

Cholangiocarcinoma is a lethal malignancy of the biliary epithelium that can arise anywhere along the biliary tract. Surgical resection confers the greatest likelihood of long-term survivability. However, its insidious onset, difficult diagnostics, and resultant advanced presentation render the majority of patients unresectable, highlighting the importance of early detection with novel biomarkers. Developing liver-directed therapies and emerging targeted therapeutics may offer improved survivability for patients with unresectable or advanced disease. In this article, the authors review the current multidisciplinary standards of care in resectable and unresectable cholangiocarcinoma, with an emphasis on novel biomarkers for early detection and nonsurgical locoregional therapy options.<br /> (© 2022 American Cancer Society.)

Details

Language :
English
ISSN :
1097-0142
Volume :
129
Issue :
2
Database :
MEDLINE
Journal :
Cancer
Publication Type :
Academic Journal
Accession number :
36382577
Full Text :
https://doi.org/10.1002/cncr.34541