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Effects of polysaccharides-riched Prunus mume fruit juice concentrate on uric acid excretion and gut microbiota in mice with adenine-induced chronic kidney disease.
- Source :
-
Current research in food science [Curr Res Food Sci] 2022 Oct 31; Vol. 5, pp. 2135-2145. Date of Electronic Publication: 2022 Oct 31 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- The present study aimed to determine the effects of polysaccharides-riched Prunus mume fruit juice concentrate (PFC) on uric acid (UA) excretion and the gut microbiota in mice with chronic kidney disease (CKD). C57BL/6 mice were randomly allocated to four groups: two that were fed AIN93M diet, one of which was administered 500 mg/kg PFC, and two that were fed AIN93M diet containing 0.2% adenine, one of which was administered 500 mg/kg PFC. PFC promoted UA excretion, which may have been mediated through increases in the protein expression of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1), organic carnitine transporter 2 (OCTN2), and reductions in the protein expression of glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) in kidneys of CKD mice. ABCG2 expression in the intestine was also increased by PFC administration. Additionally, PFC significantly increased large intestinal short-chain fatty acids (SCFAs) concentrations, and the number of gut microbial species, and reduced the abundance of the genera Bacteroides , Pseudoflavonifractor , Helicobacter , Clostridium&#95;IV and Allobaculum , which have a negative effect on UA excretion. In conclusion, PFC may promote UA excretion in CKD mice by altering the expression of urate transporters and regulating the gut microbiota.<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2022 The Authors.)
Details
- Language :
- English
- ISSN :
- 2665-9271
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Current research in food science
- Publication Type :
- Academic Journal
- Accession number :
- 36387593
- Full Text :
- https://doi.org/10.1016/j.crfs.2022.10.028