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Regulatory effect of isovitexin on MAPK/NF- κ B signal in mice with acute ulcerative colitis.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2023 Jul-Aug; Vol. 25 (8), pp. 765-782. Date of Electronic Publication: 2022 Nov 17. - Publication Year :
- 2023
-
Abstract
- The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity ( p < 0.01). In addition, isovitexin inhibited the expression of MyD88, TLR4 and NF- κ B p65 proteins. At the same time, isovitexin can inhibit the activation of MAPK/NF- κ B signaling pathway in RAW264.7 cells. In conclusion, isovitexin has a protective effect on UC mice, and its improvement mechanism of UC might be related to MAPK/NF- κ B signaling pathway.
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 25
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 36394271
- Full Text :
- https://doi.org/10.1080/10286020.2022.2142121