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Antimicrobial photodynamic therapy mediated by methylene blue in surfactant vehicle as adjuvant to periodontal treatment. Randomized, controlled, double-blind clinical trial.
- Source :
-
Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2023 Mar; Vol. 41, pp. 103194. Date of Electronic Publication: 2022 Nov 17. - Publication Year :
- 2023
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Abstract
- Background: Antimicrobial photodymanic therapy mediated by methylene blue has been investigated as an adjunctive to periodontal treatment but the dimerization of photosensitizer molecules reduces the phototoxic effects. Sodium dodecyl sulfate is a surfactant that may control this aggregation. The aim of this study was evaluated the photodynamic effect of methylene blue in sodium dodecyl sulfate in periodontitis.<br />Methods: 36 participants with periodontitis were selected and allocated randomly in two group for intervention and other two for control - all of them were treated with scaling and root planing before aPDT. Three periodontal evaluations were done: at the selection time, at the day of intervention and thirty-day after this. Pre-irradiation time was 1 min and 2 min for irradiation. Laser (Therapy XT, DMC, São Carlos, Brazil) with wavelength of 660 nm and 100 mW of power was used. Two photosensitizer solutions with 100 µM methylene blue was used, one of them was in water and other in 0,25% of sodium dodecyl sulfate. Two sites of each participant were selected for the experimental procedures. Microbiological evaluations were performed to quantify microorganisms before and immediately after intervention. Quantitative microbiological evaluation was the primary outcome; morphological aspects of bacterial colony, and clinical probing depth was the secondary one.<br />Results: There was no significant difference between the groups in both bacterial reduction and the clinical parameter evaluated.<br />Conclusion: The effect of methylene blue in surfactant did not cause enough phototoxic effects that could promote reduction of periodontal pocket depth.<br /> (Copyright © 2022. Published by Elsevier B.V.)
- Subjects :
- Humans
Photosensitizing Agents therapeutic use
Methylene Blue pharmacology
Methylene Blue therapeutic use
Surface-Active Agents
Combined Modality Therapy
Sodium Dodecyl Sulfate therapeutic use
Adjuvants, Immunologic therapeutic use
Dental Scaling
Root Planing methods
Photochemotherapy methods
Periodontitis drug therapy
Anti-Infective Agents therapeutic use
Chronic Periodontitis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1597
- Volume :
- 41
- Database :
- MEDLINE
- Journal :
- Photodiagnosis and photodynamic therapy
- Publication Type :
- Academic Journal
- Accession number :
- 36402375
- Full Text :
- https://doi.org/10.1016/j.pdpdt.2022.103194