Back to Search
Start Over
Thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in the United Kingdom.
- Source :
-
Nature communications [Nat Commun] 2022 Nov 23; Vol. 13 (1), pp. 7167. Date of Electronic Publication: 2022 Nov 23. - Publication Year :
- 2022
-
Abstract
- Population-based studies can provide important evidence on the safety of COVID-19 vaccines. Using data from the United Kingdom, here we compare observed rates of thrombosis and thrombocytopenia following vaccination against SARS-CoV-2 and infection with SARS-CoV-2 with background (expected) rates in the general population. First and second dose cohorts for ChAdOx1 or BNT162b2 between 8 December 2020 and 2 May 2021 in the United Kingdom were identified. A further cohort consisted of people with no prior COVID-19 vaccination who were infected with SARS-Cov-2 identified by a first positive PCR test between 1 September 2020 and 2 May 2021. The fourth general population cohort for background rates included those people in the database as of 1 January 2017. In total, we included 3,768,517 ChAdOx1 and 1,832,841 BNT162b2 vaccinees, 401,691 people infected with SARS-CoV-2, and 9,414,403 people from the general population. An increased risk of venous thromboembolism was seen after first dose of ChAdOx1 (standardized incidence ratio: 1.12 [95% CI: 1.05 to 1.20]), BNT162b2 (1.12 [1.03 to 1.21]), and positive PCR test (7.27 [6.86 to 7.72]). Rates of cerebral venous sinus thrombosis were higher than otherwise expected after first dose of ChAdOx1 (4.14 [2.54 to 6.76]) and a SARS-CoV-2 PCR positive test (3.74 [1.56 to 8.98]). Rates of arterial thromboembolism after vaccination were no higher than expected but were increased after a SARS-CoV-2 PCR positive test (1.39 [1.21 to 1.61]). Rates of venous thromboembolism with thrombocytopenia were higher than expected after a SARS-CoV-2 PCR positive test (5.76 [3.19 to 10.40]).<br /> (© 2022. The Author(s).)
- Subjects :
- Humans
BNT162 Vaccine
SARS-CoV-2
Vaccination adverse effects
United Kingdom
COVID-19 epidemiology
COVID-19 prevention & control
COVID-19 Vaccines adverse effects
Thrombocytopenia epidemiology
Thrombocytopenia etiology
Thrombosis epidemiology
Thrombosis etiology
Venous Thromboembolism epidemiology
Venous Thromboembolism etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 36418291
- Full Text :
- https://doi.org/10.1038/s41467-022-34668-w