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Superimposed mosaicism in cutaneous sarcoidosis: A hypothesis.

Authors :
Happle R
Wetzke M
Source :
American journal of medical genetics. Part A [Am J Med Genet A] 2023 Mar; Vol. 191 (3), pp. 899-901. Date of Electronic Publication: 2022 Nov 30.
Publication Year :
2023

Abstract

Sarcoidosis is a chronic granulomatous disorder affecting the lungs, skin, and many other organs. Twin studies suggest that genetic factors account, to a large degree, for the etiology of the disorder. Hence, theoretically, we could postulate that the phenomenon of superimposed mosaicism in the form of a pronounced segmental involvement, overlaying the disseminated non-segmental lesions, should also occur in sarcoidosis. Indeed, one case suggesting superimposed mosaicism in cutaneous sarcoidosis was found in the literature and is reassessed here.<br /> (© 2022 The Authors. American Journal of Medical Genetics Part A published by Wiley Periodicals LLC.)

Details

Language :
English
ISSN :
1552-4833
Volume :
191
Issue :
3
Database :
MEDLINE
Journal :
American journal of medical genetics. Part A
Publication Type :
Academic Journal
Accession number :
36448706
Full Text :
https://doi.org/10.1002/ajmg.a.63058