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Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study.

Authors :
Biesbroek G
Kapitein B
Kuipers IM
Gruppen MP
van Stijn D
Peros TE
van Veenendaal M
Jansen MHA
van der Zee CW
van der Kuip M
von Asmuth EGJ
Mooij MG
den Boer MEJ
Landman GW
van Houten MA
Schonenberg-Meinema D
Tutu van Furth AM
Boele van Hensbroek M
Scherpbier H
van Meijgaarden KE
Ottenhoff THM
Joosten SA
Ketharanathan N
Blink M
Brackel CLH
Zaaijer HL
Hombrink P
van den Berg JM
Buddingh EP
Kuijpers TW
Source :
PloS one [PLoS One] 2022 Nov 30; Vol. 17 (11), pp. e0266336. Date of Electronic Publication: 2022 Nov 30 (Print Publication: 2022).
Publication Year :
2022

Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe inflammatory disease in children related to SARS-CoV-2 with multisystem involvement including marked cardiac dysfunction and clinical symptoms that can resemble Kawasaki Disease (KD). We hypothesized that MIS-C and KD might have commonalities as well as unique inflammatory responses and studied these responses in both diseases. In total, fourteen children with MIS-C (n=8) and KD (n=6) were included in the period of March-June 2020. Clinical and routine blood parameters, cardiac follow-up, SARS-CoV-2-specific antibodies and CD4+ T-cell responses, and cytokine-profiles were determined in both groups. In contrast to KD patients, all MIS-C patients had positive Spike protein-specific CD3+CD4+ T-cell responses. MIS-C and KD patients displayed marked hyper-inflammation with high expression of serum cytokines, including the drug-targetable interleukin (IL)-6 and IFN-γ associated chemokines CXCL9, 10 and 11, which decreased at follow-up. No statistical differences were observed between groups. Clinical outcomes were all favourable without cardiac sequelae at 6 months follow-up. In conclusion, MIS-C and KD-patients both displayed cytokine-associated hyper-inflammation with several high levels of drug-targetable cytokines.<br />Competing Interests: The authors have declared that no competing interests exist.<br /> (Copyright: © 2022 Biesbroek et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Details

Language :
English
ISSN :
1932-6203
Volume :
17
Issue :
11
Database :
MEDLINE
Journal :
PloS one
Publication Type :
Academic Journal
Accession number :
36449533
Full Text :
https://doi.org/10.1371/journal.pone.0266336