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Potential Embolic Sources in Embolic Stroke of Undetermined Source Patients with Patent Foramen Ovale.
- Source :
-
Cerebrovascular diseases (Basel, Switzerland) [Cerebrovasc Dis] 2023; Vol. 52 (5), pp. 503-510. Date of Electronic Publication: 2022 Dec 01. - Publication Year :
- 2023
-
Abstract
- Introduction: A patent foramen ovale (PFO) may coexist with other potential embolic sources (PESs) in patients with embolic stroke of undetermined source (ESUS), leading to difficulty in attributing the stroke to either the PFO or other PESs. We aimed to investigate the prevalence and predictors of concomitant PESs in ESUS patients with PFOs.<br />Methods: A retrospective cohort study was conducted in a tertiary stroke centre. Consecutive patients with ESUS and a concomitant PFO admitted between 2012 and 2021 were included in the study. Baseline characteristics and investigations as a part of stroke workup including echocardiographic and neuroimaging data were collected. PESs were adjudicated by 2 independent neurologists after reviewing the relevant workup.<br />Results: Out of 1,487 ESUS patients, a total of 309 patients who had a concomitant PFO with mean age of 48.8 ± 13.2 years were identified during the study period. The median Risk of Paradoxical Embolism (RoPE) score for the study cohort was 6 (IQR 5-7.5). Of the 309 patients, 154 (49.8%) only had PFO, 105 (34.0%) patients had 1 other PES, 34 (11.0%) had 2 PES, and 16 (5.2%) had 3 or more PES. The most common PESs were atrial cardiopathy (23.9%), left ventricular dysfunction (22.0%), and cardiac valve disease (12.9%). The presence of additional PESs was associated with age ≥60 years (p < 0.001), RoPE score ≤6 (p ≤0.001), and the presence of comorbidities including diabetes mellitus (p = 0.004), hypertension (p≤ 0.001), and ischaemic heart disease (p = 0.011).<br />Conclusion: A large proportion of ESUS patients with PFOs had concomitant PESs. The presence of concomitant PESs was associated with older age and a lower RoPE score. Further, large cohort studies are warranted to investigate the significance of the PES and their overlap with PFOs in ESUS.<br /> (© 2022 The Author(s). Published by S. Karger AG, Basel.)
- Subjects :
- Humans
Adult
Middle Aged
Retrospective Studies
Comorbidity
Foramen Ovale, Patent complications
Foramen Ovale, Patent diagnostic imaging
Foramen Ovale, Patent epidemiology
Embolic Stroke epidemiology
Stroke diagnostic imaging
Stroke epidemiology
Stroke complications
Embolism, Paradoxical diagnostic imaging
Embolism, Paradoxical epidemiology
Embolism, Paradoxical etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9786
- Volume :
- 52
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cerebrovascular diseases (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 36455524
- Full Text :
- https://doi.org/10.1159/000527791