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Sinudenoids A-E, C 19 -Norcembranoid Diterpenes with Unusual Scaffolds from the Soft Coral Sinularia densa .
- Source :
-
Organic letters [Org Lett] 2022 Dec 16; Vol. 24 (49), pp. 9007-9011. Date of Electronic Publication: 2022 Dec 07. - Publication Year :
- 2022
-
Abstract
- Five new furanobutenolide-derived C <subscript>19</subscript> -norcembranoid diterpenes, sinudenoids A-E ( 1-5 , respectively), were isolated from the soft coral Sinularia densa . Sinudenoid A ( 1 ) possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B-D ( 2-4 , respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E ( 5 ) is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds 1-6 is proposed. Compound 5 exhibits strong anti-inflammatory activity in the zebrafish model.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 24
- Issue :
- 49
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 36475753
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c03631