Nanogrinding/ethanol activation facilitating lignin fractionation for preparation of monodispersed lignin nanoparticles.

Lignin nanoparticles (LNPs), as one of green and sustainable biological macromolecules, have attracted great attention owing to their promising potentials in many valorized fields. However, the lignin heterogeneity seriously restricts the controllable preparation of LNPs. Herein, a facile nanogrinding activation combining anhydrous ethanol dissolution process was developed to efficiently homogenize lignin prior to gradient ethanol fractionation. Two lignin fractions were obtained from nanogrinding activation/ethanol dissolution followed by gradient ethanol fractionation: L-fractions and S-fractions. Therefore, monodispersed LNPs with unique concave hollow nanostructure and large particle size, and monodispersed LNPs with solid core nanostructure and small particle size were successfully prepared from L-fractions and S-fractions, respectively, via a GVL/water anti-solvent method. The proposed LNPs formation mechanisms facilitated by nanogrinding activation/ethanol dissolution treatment were demonstrated. This study put forwards a facile and green integrated approach for monodispersed LNPs preparation with controllable morphology and particle size.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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