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Comparative study of induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone in locally advanced head and neck cancer.
- Source :
-
Journal of cancer research and therapeutics [J Cancer Res Ther] 2022 Dec; Vol. 18 (Supplement), pp. S146-S150. - Publication Year :
- 2022
-
Abstract
- Objective: Concurrent chemoradiotherapy (CTRT) is the standard treatment for patients with unresectable, nonmetastatic Locally advanced squamous cell cancer of head and neck (LASCCHN). The aim of this study to compare the efficacy and toxicity of induction chemotherapy (ICT) followed by CTRT versus standard CTRT alone in patients with LASCCHN.<br />Materials and Methods: Between January 2017 and September 2017, 100 patients with LASCCHN (Stage III and IV) were randomly assigned to two arms: 50 patients in each. Arm A treated by standard CTRT alone (a total 66 Gy in 33fr 2 Gy/# administered daily 5 days/week with 3 weekly inj. cisplatin 100 mg/m <superscript>2</superscript> divided in two days) and Arm B received two cycles of ICT (TPF - inj. paclitaxel 175 mg/m2 on day 1, cisplatin 100 mg/m2 divided in 2 days and inj. 5FU 1 gm/m2 iv d1 and d2 ) followed by same CTRT. Assessment was done weekly during RT and 1, 3, 6, 12, and 18 months posttreatment for treatment response, toxicities, and progression-free survival (PFS).<br />Results: Total response was observed 79.1% and 82.1% in Arm A and Arm B, respectively (P = 0.705) at 6-8 weeks after the completion of treatment. Acute toxicities were significantly higher in ICT arm. The 18 months PFS was 57% versus 55% in Arm A and Arm B, respectively (x <superscript>2</superscript> = 0.039, P = 0.8414).<br />Conclusion: Among the patients followed, this study failed to show benefit of ICT-CTRT over CTRT alone in patients of LASCCHN.<br />Competing Interests: None
- Subjects :
- Humans
Induction Chemotherapy adverse effects
Antineoplastic Combined Chemotherapy Protocols adverse effects
Chemoradiotherapy adverse effects
Squamous Cell Carcinoma of Head and Neck drug therapy
Cisplatin
Fluorouracil
Carcinoma, Squamous Cell pathology
Head and Neck Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1998-4138
- Volume :
- 18
- Issue :
- Supplement
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 36510955
- Full Text :
- https://doi.org/10.4103/jcrt.JCRT_936_20