Less, but better: A simplified design for T cell redirection and conditional payload delivery.

Combining immune receptor engineering with conditional expression of accessory molecules holds great promise for advancing the field of cell-based immunotherapies. In this issue of Cancer Cell, Smole et al. introduce a modular single vector system to simultaneously redirect T cell specificity toward cancer antigens while achieving activation-gated delivery of customizable payloads.
Competing Interests: Declaration of interests C.A.K. is on the scientific and/or clinical advisory boards for Achilles Therapeutics, Aleta BioTherapeutics, Bellicum Pharmaceuticals, Catamaran Bio, Obsidian Therapeutics, and T-knife; has consulted for Bristol Myers Squibb, Decheng Capital, PACT Pharma, and Roche/Genentech; and has patents broadly related to cell and gene therapy outside the scope of this work.
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