Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome.

Authors :: Garthwaite T
Sjöros T
Laine S
Koivumäki M
Vähä-Ypyä H
Eskola O
Rajander J
Kallio P
Saarenhovi M
Löyttyniemi E
Sievänen H
Houttu N
Laitinen K
Kalliokoski K
Vasankari T
Knuuti J
Heinonen I
Source :: Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2023 Mar; Vol. 33 (3), pp. 353-358. Date of Electronic Publication: 2022 Dec 22.
Publication Year :: 2023
Abstract: Objective: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).<br />Methods: Sedentary time and physical activity were measured with accelerometers and VO <subscript>2</subscript> max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [ <superscript>18</superscript> F]FDG-PET imaging.<br />Results: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO <subscript>2</subscript> max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.<br />Conclusion: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.<br /> (© 2022 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.)

Subjects :: Humans
Adult
Sedentary Behavior
Exercise
Muscle, Skeletal diagnostic imaging
Muscle, Skeletal metabolism
Glucose metabolism
Physical Fitness
Metabolic Syndrome metabolism
Cardiorespiratory Fitness

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