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Opioid-induced hyperalgesia: Are thalamic T-type calcium channels treatment targets?
- Source :
-
The Journal of clinical investigation [J Clin Invest] 2022 Dec 15; Vol. 132 (24). Date of Electronic Publication: 2022 Dec 15. - Publication Year :
- 2022
-
Abstract
- Opioid-induced hyperalgesia (OIH) is a state of paradoxically enhanced pain transmission, termed nociceptive sensitization, described to occur in both humans and animals after repeated administration of opioid drugs, including rapidly acting remifentanil. However, molecular mechanisms of OIH remain understudied. In this issue of the JCI, Yan Jin and colleagues provided strong evidence that hyperexcitable thalamocortical networks drive remifentanil-induced hyperalgesia in a rodent model of postsurgical pain. Furthermore, the authors specifically identified an important role of the CaV3.1 isoform of low-voltage-activated or T-type calcium channels (T-channels) in this process. Further experiments are needed to determine whether thalamic T channels could serve as targets for the treatment of OIH.
Details
- Language :
- English
- ISSN :
- 1558-8238
- Volume :
- 132
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- The Journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 36519545
- Full Text :
- https://doi.org/10.1172/JCI165977