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A novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration.
- Source :
-
Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Jan; Vol. 353, pp. 738-751. Date of Electronic Publication: 2022 Dec 15. - Publication Year :
- 2023
-
Abstract
- In the absence of adequate treatment, effective bone regeneration remains a great challenge. Exploring hydrogels with properties of excellent bioactivity, stability, non-immunogenicity, and commercialization is an important step to develop hydrogel-based bone regeneration materials. In this study, we engineered a self-assembled chelating peptide hydrogel loaded with an osteogenic metal ion cluster extracted from the processed pyritum decoction, including Fe <superscript>2+</superscript> , Cu <superscript>2+</superscript> , Zn <superscript>2+</superscript> , Mn <superscript>2+</superscript> , Mg <superscript>2+</superscript> , and Ca <superscript>2+</superscript> ions, named processed pyritum hydrogel (PPH). We demonstrated that as a reservoir of beneficial metal ion clusters in bone regeneration, PPH has been shown to regulate a variety of genes in the process of bone regeneration. These genes are mainly involved in extracellular matrix synthesis, cell adhesion and migration, cytokine expression, antimicrobial and inflammation. Therefore, PPH accelerated the progress of various bone healing stages, and shortened the bone healing cycle by 4 weeks. Our investigation outcomes showed that the engineered metal ion cluster hydrogel is a novel, simple, and commercializable bone-regenerating hydrogel with potential clinical use.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.<br /> (Copyright © 2022. Published by Elsevier B.V.)
- Subjects :
- Osteogenesis
Peptides
Bone and Bones
Hydrogels chemistry
Bone Regeneration
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4995
- Volume :
- 353
- Database :
- MEDLINE
- Journal :
- Journal of controlled release : official journal of the Controlled Release Society
- Publication Type :
- Academic Journal
- Accession number :
- 36526019
- Full Text :
- https://doi.org/10.1016/j.jconrel.2022.12.031