Reply to Cuervo et al and Horinouchi et al.

Competing Interests: Potential conflicts of interest. V. C. reports grants or contracts unrelated to this work from Agence Nationale pour la Recherche and Fondation pour la Recherche Médicale; consulting fees from bioMérieux, Mylan/Viatris, and Eumédica; payment or honoraria for lectures, presentations, speaker’s bureaus, manuscript writing, or educational events from Mylan/Viatris Pfizer; and support for attending meetings and/or travel from bioMérieux, Shionogi, Pfizer, and Ménarini. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.