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Choroidal Neovascularization Is Common in Best Vitelliform Macular Dystrophy and Plays a Role in Vitelliform Lesion Evolution.
- Source :
-
Ophthalmology. Retina [Ophthalmol Retina] 2023 May; Vol. 7 (5), pp. 441-449. Date of Electronic Publication: 2022 Dec 14. - Publication Year :
- 2023
-
Abstract
- Objective: Choroidal neovascularization (CNV) is usually considered to be a late-stage complication in Best vitelliform macular dystrophy (BVMD) and can be difficult to diagnose with fluorescein angiography. This study used swept-source (SS) OCT angiography (OCTA) to evaluate the prevalence of CNV in BVMD, identify structural features associated with CNV, and provide insight into the role of CNV in vitelliform lesion evolution.<br />Design: Institutional review board-approved, retrospective, cross-sectional, and longitudinal study.<br />Participants: Patients with molecularly confirmed BVMD.<br />Methods: Charts from consecutive patients with BVMD imaged with SS-OCTA (PLEX Elite 9000, Carl-Zeiss Meditec Inc) at the University of Iowa from September 2017 to October 2021 were reviewed. Clinical data, including age, gender, best-corrected visual acuity (BCVA), and treatment with intravitreal anti-VEGF injections were recorded. The presence of CNV on SS-OCTA was determined by expert graders and correlated with structural features, such as interstitial fluid, subretinal fluid, nodular subretinal pillar, focal choroidal excavation (FCE), and subfoveal choroidal thickness, with a P value of < 0.05 considered statistically significant.<br />Main Outcome Measures: Presence of CNV on SS-OCTA and correlation with structural features on SS-OCT.<br />Results: A total of 53 eyes from 27 patients (13 women; 48.1%) were included. The mean age was 45 years (range, 8-79 years), and the mean logarithm of the minimum angle of resolution BCVA was 0.38 (range, 0-1). Choroidal neovascularization was identified on SS-OCTA in 27 eyes (50.9%), of which 63.0% had a vitelliform (Gass stage 2) lesion. In 40.7% (11 of 27) of eyes, there was no prior clinical diagnosis of CNV. Other structural features associated with CNV included FCEs (15.1%, 8 of 53 eyes) and nodular pillars (15.1%, 8 of 53 eyes) (P < 0.01). Seven patients had available longitudinal imaging, and most of these patients had CNV visible on SS-OCTA (71.4%; 10 of 14 eyes).<br />Conclusion: Choroidal neovascularization is common in BVMD, including in the early stages of the disease. The presence of FCEs or nodular pillars should heighten the clinical suspicion of CNV, which may accelerate vitelliform lesion evolution.<br />Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.<br /> (Copyright © 2022 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Female
Middle Aged
Retrospective Studies
Longitudinal Studies
Cross-Sectional Studies
Tomography, Optical Coherence methods
Vitelliform Macular Dystrophy complications
Vitelliform Macular Dystrophy diagnosis
Vitelliform Macular Dystrophy pathology
Choroidal Neovascularization diagnosis
Choroidal Neovascularization drug therapy
Choroidal Neovascularization etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2468-6530
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ophthalmology. Retina
- Publication Type :
- Academic Journal
- Accession number :
- 36528270
- Full Text :
- https://doi.org/10.1016/j.oret.2022.11.014