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Effect of a 60-day weight reduction intervention prior to IVF/ICSI on perinatal outcomes in overweight or obese infertile women.
- Source :
-
Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Dec 02; Vol. 13, pp. 1062790. Date of Electronic Publication: 2022 Dec 02 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Purpose: The aim of this study was to determine whether a 60-day weight reduction intervention prior to in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) and a higher weight loss ratio effectively improved perinatal outcomes for infertile overweight or obese women.<br />Methods: This was a retrospective cohort study conducted at a university-affiliated fertility center. Two thousand three hundred and eighty-one overweight or obese infertile women who underwent or did not undergo a 60-day weight reduction intervention prior to IVF/ICSI between February 27, 2017 and November 11, 2020 were included in this study. All of these women achieved clinical pregnancy and delivered a single child after assisted reproductive technology (ART). Primary outcomes included neonatal birth weight and the incidence of pregnancy complications, premature delivery, and low birth weight.<br />Results: The body mass index (BMI), blood glucose concentration, serum insulin level, and homeostasis model assessment of insulin resistance (HOMA-IR) of the intervention group decreased significantly after the weight reduction intervention. Neonatal birth weight was significantly higher in the intervention group (3519.6 g ±484.8 g) than the control group (3406.8 g ± 554.2 g; P < 0.001). There was no significant difference in the incidence of pregnancy complications between the two groups. Linear regression analysis found that the weight reduction intervention prior to IVF/ICSI and lower HOMA-IR at ovulation induction were associated with increased birth weight. As the weight loss ratio increased, the incidence of hypertensive disorders of pregnancy, premature membrane rupture, premature delivery, stillbirth, and low birth weight showed a downward trend.<br />Conclusions: A 60-day weight reduction intervention prior to IVF/ICSI may increase neonatal birth weight, reduce maternal blood glucose concentration, and improve maternal insulin resistance in infertile overweight or obese women. This results require to be further verified by prospective randomized controlled trials with a larger sample size.<br />Competing Interests: Author NL was employed by company Zhejiang Nutriease Health Technology Company Limited. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Yang, Yang, Zheng, Zu, Ran, Wu, Ren, Lv, Kuang, Li, Du and Guan.)
- Subjects :
- Female
Humans
Infant, Newborn
Male
Pregnancy
Birth Weight
Blood Glucose
Fertilization in Vitro adverse effects
Obesity complications
Obesity therapy
Overweight complications
Overweight therapy
Pregnancy Outcome
Prospective Studies
Reproductive Techniques, Assisted adverse effects
Retrospective Studies
Semen
Sperm Injections, Intracytoplasmic
Weight Loss
Infertility, Female therapy
Infertility, Female complications
Insulin Resistance
Pregnancy Complications epidemiology
Premature Birth epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-2392
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Frontiers in endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 36531452
- Full Text :
- https://doi.org/10.3389/fendo.2022.1062790