Iron-Catalyzed, Directed Benzylic Borylation.

Authors :: Lee H
He T
Cook SP
Source :: Organic letters [Org Lett] 2023 Jan 13; Vol. 25 (1), pp. 1-4. Date of Electronic Publication: 2022 Dec 22.
Publication Year :: 2023
Abstract: Herein, we describe an iron-catalyzed benzylic C-H borylation reaction. The reaction targets primary and secondary C(sp <superscript>3</superscript> )-H bonds to deliver high-value boronic esters under mild conditions with short (7-8 min) reaction times. Functional groups are well tolerated, and complete site selectivity is observed in the presence of multiple benzylic C-H bonds.