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Nitrosoarenes Implement Cascade Cyclization of 1-Allenyl-2-alkynylbenzenes through Diradical Mechanism.
- Source :
-
Organic letters [Org Lett] 2023 Jan 13; Vol. 25 (1), pp. 82-86. Date of Electronic Publication: 2022 Dec 27. - Publication Year :
- 2023
-
Abstract
- This work reports cascade cyclization between 1-allenyl-2-alkynylbenzenes and nitrosoarenes. When these two components reacted alone under N <subscript>2</subscript> , N,O-functionalized indane-fused isoxazolidines 3 were obtained selectively. DFT calculations verify that this reaction sequence involves unprecedented nitrone/alkyne cycloadditions, followed by diradical rearrangement.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 36573784
- Full Text :
- https://doi.org/10.1021/acs.orglett.2c03884