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Evaluation of the corneal biomechanical properties and corneal thickness in patients with Graves' orbitopathy.
- Source :
-
International ophthalmology [Int Ophthalmol] 2023 Jul; Vol. 43 (7), pp. 2257-2263. Date of Electronic Publication: 2022 Dec 27. - Publication Year :
- 2023
-
Abstract
- Purpose: To evaluate the corneal biomechanical properties and central corneal thickness in patients with Graves' orbitopathy (GO).<br />Method: A total of 132 eyes of 66 patients with GO and 108 eyes of 54 healthy subjects were enrolled. Eyes with GO were classified as high score clinical activity score (CAS, ≥ 3) (Group 1, n = 64) and low CAS score (< 3) (Group 2, n = 68). Corneal biomechanical parameters [corneal hysteresis (CH), corneal resistance factor (CRF)], Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) levels were measured with Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Buffalo, NY) and compared between the groups.<br />Results: The mean CH values were found as 9.6 ± 1 mmHg in Group 1, 10.2 ± 0.9 mmHg in Group 2, and 11.4 ± 1.7 mmHg in the Control Group (p < 0.001). In post hoc analysis the mean CH was significantly lower in Group 1 than Group 2 and Control Group (Group 1-Group 2, p < 0.001; Group 1-Control Group, p < 0.001). The mean CRF was found as 10.5 ± 2.1 in Group 1, 10.4 ± 2.2 in Group 2, and 10.43 ± 2.0 in the Control group. There was no statistically significant difference between the groups in CRF measurements (p = 0.959). The mean IOPcc values were found as 17.1 ± 3.6 mmHg in Group 1, 15.8 ± 4.0 mmHg in Group 2 and 15.2 ± 4.1 mmHg in the Control Group. The IOPcc and IOPg measurements between all groups were statistically significant (p = 0.009, p = 0.027, respectively).<br />Conclusions: Corneal biomechanical measurements were different in the GO patients with varying CAS scores compared to healthy individuals.<br /> (© 2022. The Author(s), under exclusive licence to Springer Nature B.V.)
Details
- Language :
- English
- ISSN :
- 1573-2630
- Volume :
- 43
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- International ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 36574085
- Full Text :
- https://doi.org/10.1007/s10792-022-02621-x