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Aberrant cortical projections to amygdala GABAergic neurons contribute to developmental circuit dysfunction following early life stress.

Authors :
Haikonen J
Englund J
Amarilla SP
Kharybina Z
Shintyapina A
Kegler K
Garcia MS
Atanasova T
Taira T
Hartung H
Lauri SE
Source :
IScience [iScience] 2022 Dec 05; Vol. 26 (1), pp. 105724. Date of Electronic Publication: 2022 Dec 05 (Print Publication: 2023).
Publication Year :
2022

Abstract

Early life stress (ELS) results in enduring dysfunction of the corticolimbic circuitry, underlying emotional and social behavior. However, the neurobiological mechanisms involved remain elusive. Here, we have combined viral tracing and electrophysiological techniques to study the effects of maternal separation (MS) on frontolimbic connectivity and function in young (P14-21) rats. We report that aberrant prefrontal inputs to basolateral amygdala (BLA) GABAergic interneurons transiently increase the strength of feed-forward inhibition in the BLA, which raises LTP induction threshold in MS treated male rats. The enhanced GABAergic activity after MS exposure associates with lower functional synchronization within prefrontal-amygdala networks in vivo . Intriguingly, no differences in these parameters were detected in females, which were also resistant to MS dependent changes in anxiety-like behaviors. Impaired plasticity and synchronization during the sensitive period of circuit refinement may contribute to long-lasting functional changes in the prefrontal-amygdaloid circuitry that predispose to neuropsychiatric conditions later on in life.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2022 The Author(s).)

Details

Language :
English
ISSN :
2589-0042
Volume :
26
Issue :
1
Database :
MEDLINE
Journal :
IScience
Publication Type :
Academic Journal
Accession number :
36582824
Full Text :
https://doi.org/10.1016/j.isci.2022.105724