Breast Amyloidosis: A Case Report and Literature Review.

Authors :: De Crem AS
Van de Vijver K
De Visschere P
Van den Broecke R
Göker M
Source :: Journal of the Belgian Society of Radiology [J Belg Soc Radiol] 2022 Dec 19; Vol. 106 (1), pp. 134. Date of Electronic Publication: 2022 Dec 19 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Amyloidosis is an uncommon disorder characterized by extracellular accumulation of misfolded proteins in tissues. We report a unique case of localized breast amyloidosis in an asymptomatic 56-year-old woman with systemic lupus erythematosus, presented as suspicious microcalcifications without mass on mammography. Vacuum biopsy confirmed amyloidosis, producing the typical apple-green birefringence under polarized light after staining with Congo-red. Further workup and follow-up to exclude development into systemic amyloidosis or hematologic malignancy is recommended. If negative, the prognosis is very good, thus no further treatment is needed. A brief review of the literature revealed more about the typical findings and recommended management.<br />Competing Interests: The authors have no competing interests to declare.<br /> (Copyright: © 2022 The Author(s).)