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A rare case of a clear cell carcinoma in a female urethral diverticulum.

Authors :: Gonda M
Etani T
Isogai M
Kawase K
Nagai T
Sugino T
Naiki T
Hamamoto S
Kawai N
Yasui T
Source :: IJU case reports [IJU Case Rep] 2022 Oct 12; Vol. 6 (1), pp. 77-80. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2023).
Publication Year :: 2022
Abstract: Introduction: Urethral clear cell carcinoma is rare and often arises from a urethral diverticulum and rarely from the Müllerian duct. However, an explanation for this correlation remains unknown.<br />Case Presentation: We report the case of a 46-year-old woman who presented with hypermenorrhea. Magnetic resonance imaging revealed a papillary tumor in a cystic lesion in the dorsal urethra. We performed a robot-assisted radical cystourethrectomy and created an ileal conduit. Since pathological findings revealed microvascular and lymphovascular invasions around the urethra, adjuvant radiation therapy was administered. The patient showed no signs of recurrence or metastasis after treatment.<br />Conclusion: We report a case of clear cell carcinoma in a female urethral diverticulum originating from a Müllerian duct cyst. While postoperative radiation therapy has been shown to produce a good outcome in carcinoma cases similar to this one, we recommend that a radical cystourethrectomy be performed.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2022 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association.)