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SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation.
- Source :
-
Nature communications [Nat Commun] 2023 Jan 10; Vol. 14 (1), pp. 132. Date of Electronic Publication: 2023 Jan 10. - Publication Year :
- 2023
-
Abstract
- As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be considered a comorbidity for coronavirus disease 2019. Instead, current clinical evidence seems to be heading in the opposite direction. To clarify whether host factors expressed by the Cystic Fibrosis epithelia may influence coronavirus disease 2019 progression, here we describe the expression of SARS-CoV-2 receptors in primary airway epithelial cells. We show that angiotensin converting enzyme 2 (ACE2) expression and localization are regulated by Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Consistently, our results indicate that dysfunctional CFTR channels alter susceptibility to SARS-CoV-2 infection, resulting in reduced viral entry and replication in Cystic Fibrosis cells. Depending on the pattern of ACE2 expression, the SARS-CoV-2 spike (S) protein induced high levels of Interleukin 6 in healthy donor-derived primary airway epithelial cells, but a very weak response in primary Cystic Fibrosis cells. Collectively, these data support that Cystic Fibrosis condition may be at least partially protecting from SARS-CoV-2 infection.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Cystic Fibrosis Transmembrane Conductance Regulator genetics
Cystic Fibrosis Transmembrane Conductance Regulator metabolism
Down-Regulation
Receptors, Virus genetics
Receptors, Virus metabolism
Spike Glycoprotein, Coronavirus metabolism
Virus Replication
Angiotensin-Converting Enzyme 2 genetics
Angiotensin-Converting Enzyme 2 metabolism
COVID-19
Cystic Fibrosis genetics
SARS-CoV-2 physiology
Virus Internalization
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 36627352
- Full Text :
- https://doi.org/10.1038/s41467-023-35862-0