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Women on diuretics have a higher risk of hospital admission because of hyponatremia than men.

Authors :
Hendriksen LC
van der Linden PD
Herings RMC
Stricker BH
Visser LE
Source :
Pharmacoepidemiology and drug safety [Pharmacoepidemiol Drug Saf] 2023 Jun; Vol. 32 (6), pp. 635-642. Date of Electronic Publication: 2023 Jan 22.
Publication Year :
2023

Abstract

Purpose: Recent studies suggest that women are more susceptible to diuretic-induced hyponatremia resulting in hospital admission than men. The aim of this study was to confirm whether these sex differences in hyponatremia-related hospital admissions in diuretic users remain after adjusting for several confounding variables such as age, dose, and concurrent medication.<br />Methods: In a case-control design nested in diuretic users, cases of hyponatremia associated hospital admissions between 2005 and 2017 were identified from the PHARMO Data Network. Cases were 1:10 matched to diuretic users as controls. Odds ratios (OR) with 95%CIs were calculated for women versus men and adjusted for potential confounders (age, number of diuretics, other hyponatremia-inducing drugs, chronic disease score) using unconditional logistic regression analysis. A subgroup analysis was performed for specific diuretic groups (thiazides, loop diuretics and aldosterone antagonists).<br />Results: Women had a statistically significantly higher risk of a hospital admission associated with hyponatremia than men while using diuretics (OR 1.86, 95%CI 1.64-2.11). Adjusting for the potential confounders resulted in an increased risk for women compared to men (ORadj 2.65, 95% CI 2.31-3.04). This higher risk in women was also seen in the three subgroup analyses after adjustment.<br />Conclusion: Our findings show a higher risk of hyponatremia-related hospital admission in women than men while using diuretics. Further research is needed to understand the underlying mechanism of this sex difference to be able to provide sex-specific recommendations.<br /> (© 2023 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1099-1557
Volume :
32
Issue :
6
Database :
MEDLINE
Journal :
Pharmacoepidemiology and drug safety
Publication Type :
Academic Journal
Accession number :
36633523
Full Text :
https://doi.org/10.1002/pds.5592