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Investigating Neutrophil-to-Lymphocyte and C-Reactive Protein-to-Albumin Ratios in Type 2 Diabetic Patients with Dry Eye Disease.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2024 Aug; Vol. 32 (6), pp. 925-931. Date of Electronic Publication: 2023 Jan 13. - Publication Year :
- 2024
-
Abstract
- Background: Patients with Diabetes mellitus (DM) are at risk of developing dry eye disease (DED). We investigated routine laboratory parameters in patients with type 2 DM (T2D) and T2D-DED to identify potential inflammatory markers.<br />Methods: A retrospective study of 241 randomly selected patients (30 DED non-diabetic, 120 T2D, and 91 with T2D-DED). The neutrophil-to-lymphocyte ratios (NLR), CRP-to-albumin ratios (CAR), and the glycosylated haemoglobin A1c (HbA1c) results were correlated between groups.<br />Results: The NLR and HbA1c were significantly higher in the T2D-DED group (p≤0.001 and 0.0001, respectively) when compared with T2D and DED non-diabetic groups. CAR was insignificantly high in the three groups (p=0.192). A positive correlation was identified between CAR and NLR in T2D-DED patients (p= 0.008).<br />Conclusion: In T2D-DED patients, NLR was significantly high and positively correlate with CAR. These results predicate diabetes with dry eye complications, and biomarker-mediated inflammation may have important roles in DED pathogenesis.
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Aged
Glycated Hemoglobin metabolism
Serum Albumin metabolism
Adult
Dry Eye Syndromes blood
Dry Eye Syndromes diagnosis
Dry Eye Syndromes metabolism
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Neutrophils
C-Reactive Protein metabolism
Lymphocytes
Biomarkers blood
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 36637884
- Full Text :
- https://doi.org/10.1080/09273948.2022.2152698