Brief overview of primary mesenchymal chondrosarcoma and discussion of a case report.

Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-22-2284/coif). The author RLR receives royalties and has licenses with Onkos, Zimmer Biomet, and Daichii Sankyo, has received consulting fees from Onkos, Zimmer Biomet, and Daichii Sankyo, has received payment or Honoria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Onkos, and has leadership or fiduciary role in other board, society, committee or advocacy group, paid or unpaid through SFA and MSTS. The other authors have no conflicts of interest to declare.