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Compound K: A systematic review of its anticancer properties and probable mechanisms.
- Source :
-
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2023 Aug; Vol. 37 (4), pp. 684-712. Date of Electronic Publication: 2023 Jan 31. - Publication Year :
- 2023
-
Abstract
- Panax ginseng is a common natural product, which is well-known to have a wide range of pharmacological activities in cancer. Its metabolite, compound K (CK), has been reported to have anticancer activity. We aimed to systematically review the literature for evidence of anticancer effects of CK. We conducted a systematic search in eight databases. We included all in vitro and in vivo studies investigating the anticancer effects of CK with no restrictions. Quality assessment was applied by ToxRTool. Fifty-four articles were included in our study. The purity of CK in our included studies was at least 95%. The in vitro studies reported that CK had a potential anticancer activity on several cell lines including human lung cancer cell lines (A549, PC-9), nasopharyngeal carcinoma cell line (Hk-1), liver cancer cell line (BEL 7402), and pediatric acute myeloid leukemia cell lines (Kasumi-1, MV4-11). The in vivo studies reported a significant decrease in tumor volume in mice treated with CK. CK is a potential supplementary treatment in cancer chemotherapies. The safety and further clinical trials of CK should be explored for future drug development.<br /> (© 2023 Société Française de Pharmacologie et de Thérapeutique.)
Details
- Language :
- English
- ISSN :
- 1472-8206
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Fundamental & clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 36691721
- Full Text :
- https://doi.org/10.1111/fcp.12874