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L-Fucose Suppresses Lipid Accumulation via the AMPK Pathway in 3T3-L1 Adipocytes.

L-Fucose Suppresses Lipid Accumulation via the AMPK Pathway in 3T3-L1 Adipocytes.

Authors :
Nakao T
Otaki S
Kominami Y
Watanabe S
Ito M
Aizawa T
Akahori Y
Ushio H
Source :
Nutrients [Nutrients] 2023 Jan 18; Vol. 15 (3). Date of Electronic Publication: 2023 Jan 18.
Publication Year :
2023

Abstract

L-fucose (Fuc), a monosaccharide with different biological functions in various organisms, exhibits potent anti-obesity effects in obese mice. However, the mechanisms underlying its anti-obesity effects remain largely unknown. In this study, we aimed to investigate the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. We found that Fuc treatment suppressed lipid accumulation during adipocyte differentiation. Additionally, Fuc treatment enhanced the phosphorylation of AMP-activated kinase (AMPK) and its downstream pathways, responsible for the regulation of fatty acid oxidation and lipolysis. Furthermore, Fuc-induced activation of the AMPK pathway was diminished by the AMPK inhibitor Compound C, and Fuc treatment considerably promoted glucose uptake via Akt activation in an insulin-resistant state. These findings provide a basis for elucidating the mechanism underlying the anti-obesity effect of Fuc, which may, in the future, be considered as a therapeutic compound for treating obesity and related diseases.

Details

Language :
English
ISSN :
2072-6643
Volume :
15
Issue :
3
Database :
MEDLINE
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
36771210
Full Text :
https://doi.org/10.3390/nu15030503