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A chlorin e6 derivative-mediated photodynamic therapy inhibits cutaneous squamous cell carcinoma cell proliferation via Akt/mTOR signaling pathway.
- Source :
-
Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2023 Jun; Vol. 42, pp. 103332. Date of Electronic Publication: 2023 Feb 14. - Publication Year :
- 2023
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Abstract
- Background and Objectives: Although most cutaneous squamous cell carcinoma (cSCC) cases are generally nonlethal and manageable with surgical excision, there ares till significant hazards for patients who are ineligible for surgical resection. We sought to find a suitable and effective treatment for cSCC.<br />Methods: We modified chlorin e6 by adding a hydrogen chain with a six-carbon ring to the benzene ring and named this new photosensitizer as STBF. We first investigated the fluorescence characteristics, cellular uptake of STBF and subcellular localization. Next, cell viability was detected by CCK-8 assay and the TUNEL staining was performed. Akt/mTOR-related proteins were examined by western blot.<br />Results: STBF-photodynamic therapy (PDT) inhibits cSCC cells viability in a light dose dependent manner. The antitumor mechanism of STBF-PDT might be due to the suppression of the Akt/mTOR signaling pathway. Further animal investigation determined that STBF-PDT led to a marked reduction in tumor growth.<br />Conclusions: Our results suggest that STBF-PDT exerts significant therapeutic effects in cSCC. Thus, STBF-PDT is expected to be a promising method for the treatment of cSCC and the photosensitizer STBF may be destined for a wider range of applications in photodynamic therapy.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Photosensitizing Agents therapeutic use
Proto-Oncogene Proteins c-akt
Signal Transduction
TOR Serine-Threonine Kinases metabolism
Cell Proliferation
Cell Line, Tumor
Carcinoma, Squamous Cell drug therapy
Carcinoma, Squamous Cell metabolism
Photochemotherapy methods
Skin Neoplasms drug therapy
Skin Neoplasms metabolism
Porphyrins
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1597
- Volume :
- 42
- Database :
- MEDLINE
- Journal :
- Photodiagnosis and photodynamic therapy
- Publication Type :
- Academic Journal
- Accession number :
- 36796744
- Full Text :
- https://doi.org/10.1016/j.pdpdt.2023.103332