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Assessing Epstein-Barr virus in gastric cancer: clinicopathological features and prognostic implications.

Authors :
Li G
Zhou Z
Wang Z
Wang Z
Source :
Infectious agents and cancer [Infect Agent Cancer] 2023 Feb 19; Vol. 18 (1), pp. 11. Date of Electronic Publication: 2023 Feb 19.
Publication Year :
2023

Abstract

Background: Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) was a unique molecular subtype of gastric cancer (GC). However, the clinicopathological characteristics and prognostic role of EBV infection remains unclear. We aimed to evaluate the clinicopathological features of EBVaGC and its role on prognosis.<br />Methods: EBV-encoded RNA (EBER) in situ hybridization method was used to evaluate the EBV status in GC. The serum tumor markers AFP, CEA, CA19-9 and CA125 of patients were detected before treatment. HER2 expression and microsatellite instability (MSI) status was evaluated according to established criteria. The relationship between EBV infection and clinicopathological factors as well as its role on prognosis were investigated.<br />Results: 420 patients were enrolled in the study and of 53 patients (12.62%) were identified as EBVaGC. EBVaGC was more common in males (p = 0.001) and related to early T stage (p = 0.045), early TNM stage (p = 0.001) and lower level of serum CEA (p = 0.039). No association could be found between EBV infection and HER2 expression, MSI status and other factors (p all > 0.05). Kaplan-Meier analysis revealed that both the overall survival and disease-free survival of EBVaGC patients were similar to that of EBV-negative GC (EBVnGC) patients (p = 0.309 and p = 0.264, respectively).<br />Conclusion: EBVaGC was more common in males and in patients with the early T stage and TNM stage as well as patients with lower serum CEA level. Difference in overall survival and disease-free survival between EBVaGC and EBVnGC patients cannot be detected.<br /> (© 2023. The Author(s).)

Details

Language :
English
ISSN :
1750-9378
Volume :
18
Issue :
1
Database :
MEDLINE
Journal :
Infectious agents and cancer
Publication Type :
Academic Journal
Accession number :
36803802
Full Text :
https://doi.org/10.1186/s13027-023-00489-9