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[Latest updates on immunotactoid glomerulopathy and fibrillary glomerulonephritis].
- Source :
-
Bulletin du cancer [Bull Cancer] 2024 Jul-Aug; Vol. 111 (7-8), pp. 741-747. Date of Electronic Publication: 2023 Feb 15. - Publication Year :
- 2024
-
Abstract
- Various hematologic malignancies can lead to renal complications. The most common of these hemopathies to affect the kidney is multiple myeloma, however an increasing number of kidney diseases are associated with other monoclonal gammopathies. It is recognized that clones in small abundance can be responsible for severe organ damage, thus the concept of monoclonal gammopathy of renal significance (MGRS) has emerged. Although the hemopathy in these patients is more consistent with monoclonal gammopathy of undetermined significance (MGUS) than with multiple myeloma, the diagnosis of a renal complication changes the therapeutic management. Preservation and restoration of renal function is possible with treatment targeting the responsible clone. In this article, we take as an example immunotactoid and fibrillary glomerulopathies, two distinct entities with different etiologies and consequently different management. Immunotactoid glomerulopathy is most often associated with monoclonal gammopathy or chronic lymphocytic leukemia, the deposits on renal biopsy are monotypic, and treatment is therefore based on clone targeting. Fibrillary glomerulonephritis, on the other hand, is caused by autoimmune diseases or solid cancers. Deposits on renal biopsy are in the vast majority polyclonal. There is a specific immunohistochemical marker, DNAJB9, and treatment is less well established.<br /> (Copyright © 2023 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Humans
Multiple Myeloma complications
Multiple Myeloma pathology
Multiple Myeloma therapy
Paraproteinemias complications
Paraproteinemias therapy
Paraproteinemias pathology
Leukemia, Lymphocytic, Chronic, B-Cell complications
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Leukemia, Lymphocytic, Chronic, B-Cell therapy
Monoclonal Gammopathy of Undetermined Significance complications
Monoclonal Gammopathy of Undetermined Significance therapy
Monoclonal Gammopathy of Undetermined Significance pathology
Glomerulonephritis pathology
Glomerulonephritis etiology
Glomerulonephritis therapy
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6917
- Volume :
- 111
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Bulletin du cancer
- Publication Type :
- Academic Journal
- Accession number :
- 36803980
- Full Text :
- https://doi.org/10.1016/j.bulcan.2022.12.014