Chemical constituents of Ajuga forrestii and their anti-ferroptosis activity.

Authors :: Shi H
Jiang X
Cao L
Peng X
Tan Q
Teng X
Gu Q
He L
Source :: Fitoterapia [Fitoterapia] 2023 Apr; Vol. 166, pp. 105461. Date of Electronic Publication: 2023 Feb 18.
Publication Year :: 2023
Abstract: Six new neoclerodane diterpenoids (1-6), along with ten known compounds (7-16), were isolated from Ajuga forrestii. Their structures were elucidated by HRESIMS, 1D and 2D NMR, ECD calculation, and single-crystal X-ray diffraction analysis. The structure of a known neoclerodane diterpene ajudecunoid C (6) was revised based on the reported NMR empirical rules. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, compounds 8, 9, and 12 significantly inhibited RSL3-induced ferroptosis with EC <subscript>50</subscript> values of 0.45 μM, 0.076 μM, and 0.14 μM.<br />Competing Interests: Declaration of Competing Interest The authors declared that they have no conflicts of interest to this work.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)