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GLP-1 RAs in Spain: A Short Narrative Review of Their Use in Real Clinical Practice.
- Source :
-
Advances in therapy [Adv Ther] 2023 Apr; Vol. 40 (4), pp. 1418-1429. Date of Electronic Publication: 2023 Feb 23. - Publication Year :
- 2023
-
Abstract
- Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are a class of drugs with potent glucose-lowering activity. Additionally, some GLP-1 RAs have demonstrated cardiovascular and renal benefits. Current guidelines recommend their use in patients with type 2 diabetes (T2D) at high risk of or with established cardiovascular disease (CVD), regardless of glycaemic control, with lifestyle modification and metformin. However, several studies have recently highlighted the limited number of patients with T2D benefiting from these medications worldwide. Given the huge burden of CVD among patients with T2D, efforts should be made to bring clinical practice closer to expert guidelines. This review describes the current situation of GLP-1 RA use in Spain and the reasons behind the gap between guidelines and real-world practice and suggests possible solutions. Administrative issues, lack of awareness of the cardiovascular benefits, clinical inertia, rejection of injectable medication and costs could be some of the reasons for the current situation. Possible strategies that could help to close the gap include encouraging a multidisciplinary approach to the treatment of diabetes which involves cardiologists, endocrinologists, nephrologists, primary care providers and pharmacists; improved awareness of comorbidities and earlier evaluation and treatment or risks; and better education of healthcare providers regarding the cardioprotective benefits of these drugs.<br /> (© 2023. The Author(s).)
- Subjects :
- Humans
Glucagon-Like Peptide 1 antagonists & inhibitors
Glucagon-Like Peptide-1 Receptor agonists
Hypoglycemic Agents therapeutic use
Spain
Cardiovascular Diseases drug therapy
Cardiovascular Diseases chemically induced
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1865-8652
- Volume :
- 40
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Advances in therapy
- Publication Type :
- Academic Journal
- Accession number :
- 36821026
- Full Text :
- https://doi.org/10.1007/s12325-023-02442-z